Fig 5. Co-expression of t(8;21)-specific genes.

(A) Heatmaps showing the clustering of 827 t(8;21)-specific genes in 64 pediatric AML samples. (B) Co-expressed genes were determined based on the coefficient of determination (R2 > 0.6). The co-expression gene networks were generated using Cytoscape 2.8.3[19]. Node color is based on the fold change of the differentially expressed gene (red: up-regulated; green: down-regulated), and node size corresponds to the degree of the node (i.e., the number of edges incident to it). (C) Gene expression of the HOX gene family for three types of cytogenetic abnormalities, where NK is separated into two groups based on the mutation of FLT3/ITD.