Table 1. Most significantly up- and down-regulated genes in the three cytogenetic categories.
| t(8; 21) | Inv(16) | Normal | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Up-regulation | Down-regulation | Up-regulation | Down-regulation | Up-regulation | Down-regulation | ||||||
| Gene | p-value | Gene | p-value | Gene | p-value | Gene | p-value | Gene | p-value | Gene | p-value |
| RUNX1T1 | 2.21E-31 | RFX8 | 7.18E-20 | MMP14 | 7.06E-22 | COL23A1 | 1.02E-09 | NKX2-3 | 6.60E-17 | ADARB2-AS1 | 7.85E-11 |
| CTC-497E21.4 | 7.55E-22 | TSPAN32 | 5.14E-19 | AK5 | 5.32E-21 | RP1-249H1.4 | 5.98E-09 | RP11-129J12.2 | 1.73E-10 | MMP28 | 5.70E-10 |
| SIPA1L2 | 7.91E-19 | MEIS1 | 7.02E-17 | XPNPEP2 | 2.79E-16 | RP11-1055B8.6 | 1.47E-08 | RP11-1055B8.6 | 7.16E-10 | RP11-1134I14.2 | 1.51E-09 |
| TRH | 3.55E-18 | RP11-556E13.1 | 5.44E-16 | EMILIN1 | 3.26E-16 | RANBP17 | 3.05E-07 | PRDM16 | 1.51E-09 | KIRREL | 2.42E-09 |
| WIPF3 | 4.34E-14 | HOXB2 | 8.00E-14 | CHI3L1 | 9.33E-11 | DBN1 | 8.50E-06 | BAHCC1 | 2.42E-09 | LAMB2 | 2.42E-09 |
| POU4F1 | 9.74E-13 | C11orf21 | 2.28E-13 | CD9 | 2.44E-10 | TANC2 | 2.08E-05 | RP1-163G9.1 | 2.91E-09 | DLGAP3 | 4.84E-09 |
| PALM | 1.06E-12 | ARHGEF11 | 1.19E-11 | SPARC | 2.44E-10 | DNAJC12 | 3.50E-05 | TSPAN32 | 1.25E-07 | CD52 | 6.48E-09 |
| AC141928.1 | 2.37E-12 | HOXB-AS1 | 2.77E-11 | TGFBI | 2.44E-10 | CD59 | 5.15E-05 | PLXNC1 | 2.86E-07 | RUNX1T1 | 8.99E-09 |
| PSD3 | 1.86E-11 | AC004540.5 | 2.99E-11 | LPAR1 | 4.57E-10 | CYP7B1 | 5.39E-05 | CTD-3179P9.1 | 5.31E-07 | PEAR1 | 1.44E-08 |
| IRX6 | 1.07E-10 | LAT2 | 3.96E-11 | ME1 | 1.18E-09 | SPATA6 | 6.71E-05 | SEL1L3 | 1.21E-06 | AADAT | 1.63E-08 |
| GAPDHP14 | 1.24E-10 | HOXB4 | 1.70E-10 | GPR12 | 2.14E-09 | NR6A1 | 7.13E-05 | AIG1 | 2.17E-06 | PSD3 | 2.58E-08 |
| IGSF1 | 1.37E-10 | CPVL | 2.56E-10 | COBLL1 | 2.67E-09 | CTC-455F18.3 | 1.52E-04 | CTSG | 3.26E-06 | CERS4 | 1.42E-07 |
| SGPP1 | 1.55E-10 | HOXA-AS4 | 3.69E-10 | CLIP3 | 5.54E-09 | RP11-480D4.3 | 1.72E-04 | MIR4740 | 5.05E-06 | RP11-567J24.4 | 1.11E-06 |
| DOCK6 | 6.10E-10 | HOXA10 | 5.79E-10 | LSAMP | 7.66E-09 | PCNXL2 | 1.83E-04 | RP11-1055B8.4 | 1.86E-05 | ST18 | 1.62E-06 |
| EVC2 | 1.24E-09 | C1orf127 | 8.84E-10 | CD1B | 8.22E-09 | LRRC37A16P | 1.83E-04 | TRGC1 | 2.27E-05 | TPO | 1.71E-06 |
| SLCO5A1 | 1.32E-09 | HOXA9 | 1.80E-09 | EMP1 | 2.93E-08 | BAHCC1 | 1.94E-04 | OCLN | 2.63E-05 | SGK110 | 3.89E-06 |
| PLCG1 | 1.67E-09 | DOCK1 | 2.79E-09 | CYP2E1 | 3.19E-08 | NKX2-3 | 2.47E-04 | BEND6 | 2.63E-05 | ALS2CL | 3.89E-06 |
| GYLTL1B | 2.35E-09 | HOXB3 | 9.41E-09 | NT5E | 6.47E-08 | RP5-862P8.2 | 2.47E-04 | HOXA10 | 2.85E-05 | CCDC50 | 5.05E-06 |