Fig. 2. Serum APE1/Ref-1 in coronary artery disease. Serum APE1/Ref-1 was assayed by ELISA. Each bar shows the mean±standard error of the mean. A. The levels of serum APE1/Ref-1 are higher in patients with myocardial infarction (MI) than angina. ^*p<0.01, control vs. angina and angina vs. MI, ^**p<0.001, control vs. MI. B. Serum APE1/Ref-1 is not significantly different between the non-ST elevation myocardial infarction (NSTEMI) and STEMI patients. ^*p<0.01, ns; non-specific. C. Serum APE1/Ref-1 levels are associated with thrombolysis in myocardial infarction (TIMI) grade flow in acute coronary syndrome (ACS). TIMI flow 0-2 shows higher levels of APE1/Ref-1 than TIMI 3. ^*p<0.01, TIMI 3 vs. TIMI 0-2. D. The elevated APE1/Ref-1 decreased 4 days after CAG from 1.62±0.27 ng/100 µL to 0.35±0.23 ng/100 µL. ^*p<0.01. APE1/Ref-1: apurinic/apyrimidinic endonuclease 1/redox effector factor 1, CAG: coronary angiograms.