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. 2015 Apr 30;135(8):2077–2083. doi: 10.1038/jid.2015.128

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Copyright © 2015 The Society for Investigative Dermatology, Inc

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Identification of differences in DNA methylation between psoriasis and controls. Scatter plot between methylation changes (delta-beta, psoriasis PRE-UV vs. controls) and corresponding −log₁₀(false-discovery rate (FDR) adj. P-value) for total assessed 470,903 sites was shown. CpG sites with delta-beta>0.2 and −log₁₀(FDR adj. P-value)>2 were defined as methylation variable positions (MVPs). The upper square indicates hypermethylated MVPs, and the bottom square indicates hypomethylated MVPs in psoriasis compared with controls.