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Animal experimental design
| Group | Vaccine | Dose (TCID50 unless otherwise specified) | No. of piglets | Boost interval (wk) | Challenge with strain: |
|||
|---|---|---|---|---|---|---|---|---|
| PRVTJ |
CSFV Shimen |
|||||||
| Interval (wk) | Dose (TCID50) | Interval (wk) | Dose (TCID50) | |||||
| 1 | rPRVTJ-delgE/gI-E2 | 106 | 5 | 1 | 106 | 5 | 106 | |
| 2 | rPRVTJ-delgE/gI-E2 | 105 | 5 | 3 | 1 | 106 | 5 | 106 |
| 3 | rPRVTJ-delgE/gI-E2 | 104 | 5 | 3 | 1 | 106 | 5 | 106 |
| 4 | rPRVTJ-delgE | 105 | 5 | 1 | 106 | |||
| 5 | DMEM | 1 ml | 5 | 1 | 106 | |||
| 6 | C-strain | One dose | 5 | 3 | 5 | 106 | ||
| 7 | PBS | 1 ml | 5 | 5 | 106 | |||
