TABLE 3.
Folate metabolite concentrations by DHFR 19 bp genotype group in healthy young Irish adults1
| DHFR 19 bp genotype | Red blood cell folate, nmol/L | Serum folate, nmol/L | Plasma tHcy, μmol/L |
| wt/wt (n = 828) | 1010 (786, 1320) | 30.0 (21.0, 42.6) | 8.2 (7.0, 9.7) |
| wt/del (n = 1204) | 1010 (755, 1320) | 29.3 (20.7, 43.6) | 8.2 (7.1, 9.7) |
| del/del (n = 470) | 990 (757, 1270) | 30.9 (21.2, 44.5) | 8.0 (6.9, 9.4) |
| P | 0.20 | 0.77 | 0.21 |
1
Values are medians (IQRs). P values are from linear regression analysis after application of rank-based inverse normal transformation. Full regression analysis values are in Supplemental Table 1. del, deletion; DHFR, dihydrofolate reductase; tHcy, total homocysteine; wt, wild-type.