Figure 4.
PI3K inhibitors induce apoptosis in CLL B cells. CLL cell viability was determined 24, 48, and 72 hours after addition of the PI3K inhibitors that are displayed on the vertical axis by staining with DiOC6 and PI. The results represent the mean (± SEM; n = 7) relative viability of PI3K inhibitor treated CLL B cells compared with untreated controls (100%). The strongest cytotoxic effects at 1 μM and 10 μM were obtained with PIK-90 and PI-103, whereas TGX115 and IC87114 were found to be less potent. *Significant decrease in viability (P < .05).