Figure 7. Effect of 1 on blood glucose during oral and intraperitoneal glucose administration, and pyruvate challenge.

C57BL/6J mice were treated with 1 at 50 mg kg⁻¹ (blue lines) or with vehicle (grey lines) intraperitoneally, and plasma glucose concentrations measured before (−15 min) and after (a) intraperitoneal (IP) glucose (1.5 g kg⁻¹, at t=0), (b) oral glucose (2 g kg⁻¹, at t=0), (c) pyruvate (2 g kg, at t=0). Inserts represent AUC _{(−15 to 120)}. (1: blue bars; vehicle: grey bars) measured at the indicated time points. Data are mean±s.e.m (n=6 mice per group). two-sided t-test *P<0.05; **P<0.01; ***P<0.001.