Table 3.
Details of mutations identified in tumor tissue and in plasma at Cycle 1 Day 1 on the PGM platform. ND: not detected.
| TUMOR | PLASMA | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| PGM | PGM | ||||||||
| N° | Tumor Type | Gene | Mutation | % | Coverage | Gene | Mutation | % | Coverage |
| #1 | Colorectal cancer | KRAS | G12V | 46 | 820 | KRAS | G12V | 19 | 630 |
| TP53 | R248Q | 31 | 991 | TP53 | R248Q | 9 | 1997 | ||
| TP53 | R158fs*11 | 50 | 825 | TP53 | R158fs*11 | 16 | 1008 | ||
| APC | A1492fs*15 | 44 | 989 | APC | A1492fs*15 | 15 | 746 | ||
| #2 | Breast cancer | TP53 | H193Y | 37 | 1008 | TP53 | H193Y | ND | 3187 |
| #3 | Ovarian cancer | TP53 | S96fs*53 | 87 | 368 | TP53 | S96fs*53 | ND | 879 |
| #4 | Ovarian cancer | KRAS | G12D | 20 | 1555 | KRAS | G12D | ND | 473 |
| PIK3CA | E545K | 23 | 1717 | PIK3CA | E545K | ND | 678 | ||
| #5 | Colorectal cancer | FBXW7 | S582L | 31 | 1744 | FBXW7 | S582L | 46 | 1998 |
| PIK3CA | E542K | 31 | 1010 | PIK3CA | E542K | 58 | 1994 | ||
| TP53 | R282W | 31 | 1447 | TP53 | R282W | 43 | 904 | ||
| #6 | Breast cancer | KRAS | G12S | 43 | 533 | KRAS | G12S | 3 | 1519 |
| PIK3CA | N1044S | 39 | 516 | PIK3CA | N1044S | 9.1 | 986 | ||
| #7 | Colorectal cancer | PIK3CA | Q546K | 26 | 754 | PIK3CA | Q546K | 31 | 6509 |
| TP53 | Y234* | 28 | 640 | TP53 | Y234* | 57 | 8395 | ||
| KRAS | G12C | 19 | 772 | KRAS | G12C | 36 | 1723 | ||
| APC | E1374* | 30 | 712 | APC | E1374* | 33 | 2116 | ||
| #8 | Ovarian cancer | PIK3CA | E545K | 16 | 6676 | PIK3CA | E545K | ND | 2333 |
| KRAS | G12D | 29 | 6801 | KRAS | G12D | ND | 522 | ||
| #9 | Ovarian cancer | TP53 | Y220C | ND | 700 | TP53 | Y220C | 5.4 | 1162 |
| #10 | Ovarian cancer | PIK3CA | E542K | 40 | 7169 | PIK3CA | E542K | ND | 3895 |
| #11 | Ovarian cancer | TP53 | R175H | 67 | 255 | TP53 | R175H | ND | 858 |
| #12 | Breast cancer | TP53 | H179R | 90 | 353 | TP53 | H179R | 13.6 | 655 |
| #13 | Breast cancer | TP53 | R175H | 23 | 175 | TP53 | R175H | 7.6 | 1799 |
| TP53 | D281H | 17 | 281 | TP53 | D281H | 2 | 1756 | ||
| #14 | Bladder cancer | CDKN2A | H83Y | 76 | 212 | CDKN2A | H83Y | 4 | 1626 |
| #15 | Colorectal cancer | NRAS | G12S | 37 | 2662 | NRAS | G12S | 51 | 1088 |
| #16 | Colorectal cancer | KRAS | G12D | 25 | 907 | KRAS | G12D | 7.9 | 665 |
| PIK3CA | Q546R | 24 | 1130 | PIK3CA | Q546R | 13 | 1785 | ||
| TP53 | G244D | 33 | 930 | TP53 | G244D | 6,7 | 2100 | ||
| #17 | Breast cancer | TP53 | R342fs*2 | 30 | 238 | TP53 | R342fs*2 | 23 | 1214 |
| #18 | Penile cancer | PIK3CA | E545K | 9,1 | 1483 | PIK3CA | E545K | 4.9 | 1763 |
| #19 | Ovarian cancer | TP53 | A138P | 64 | 446 | TP53 | A138P | ND | 2413 |
| PTEN | EXON3-4S | 26 | 899 | PTEN | EXON3-4S | ND | 1237 | ||
| #20 | Lung adenocarcinoma | KRAS | G12C | 57 | 2084 | KRAS | G12C | ND | 849 |
| #21 | Endometrial cancer | TP53 | P190L | 89 | 1213 | TP53 | P190L | <1% | 7044 |
| #22 | Ovarian cancer | PTEN | L70fs*4 | 11,5 | 1795 | PTEN | L70fs*4 | ND | 546 |
| #23 | Colorectal cancer | KRAS | G12V | 40 | 1705 | KRAS | G12V | 4.4 | 1365 |
| TP53 | R175H | 58 | 151 | TP53 | R175H | ND | 686 | ||
| #24 | Glioblastoma | TP53 | K132N | 65 | 689 | TP53 | K132N | ND | 37094 |
| PIK3CA | E542K | 33 | 954 | PIK3CA | E542K | ND | 33631 | ||
| #25 | Colorectal cancer | KRAS | G12V | 43 | 2380 | KRAS | G12V | ND | 1119 |
| PTEN | V317fs* | 28 | 1938 | PTEN | V317fs* | ND | 1300 | ||
| TP53 | R273C | 65 | 2231 | TP53 | R273C | ND | 373 | ||
| #26 | Colorectal cancer | KRAS | Q61H | 75 | 5376 | KRAS | Q61H | 51 | 2960 |
| APC | S1501A | 57 | 937 | APC | S1501A | 28 | 1915 | ||
| APC | S1495fs*14 | 41 | 2213 | APC | S1495fs*14 | 26 | 1790 | ||
| SMAD4 | G386R | 49 | 1171 | SMAD4 | G386R | 26 | 280 | ||
| ATM | R337C | 42 | 1179 | ATM | R337C | 18 | 781 | ||
| #27 | Colorectal cancer | KRAS | G12V | 40 | 1897 | KRAS | G12V | ND | 4627 |
| TP53 | P151S | 45 | 247 | TP53 | P151S | ND | 2776 | ||
| #28 | Breast cancer | PIK3CA | E545K | 16 | 1183 | PIK3CA | E545K | ND | 2327 |
| PTEN | L325R | 22 | 851 | PTEN | L325R | ND | 1661 | ||
| PTEN | E235fs*2 | 11 | 922 | PTEN | E235fs*2 | ND | 1495 | ||
| TP53 | N210fs*54 | 39 | 524 | TP53 | N210fs*54 | ND | 3450 | ||
| #29 | Breast cancer | TP53 | E171* | 70 | 240 | TP53 | E171* | 6.5 | 740 |
| #30 | Melanoma | BRAF | V600E | 58 | 1395 | BRAF | V600E | ND | 2238 |
| #31 | Colorectal cancer | KRAS | G12D | 8 | 1845 | KRAS | G12D | 3.4 | 567 |
| APC | R1114* | 9 | 3491 | APC | R1114* | ND | 685 | ||
| #32 | Glioblastoma | FBXW7 | R484K | 6 | 439 | FBXW7 | R484K | ND | 5600 |
| #33 | Bladder cancer | PIK3CA | E545K | 28 | 3253 | PIK3CA | E545K | 8.5 | 778 |
| TP53 | E180K | 12 | 899 | TP53 | E180K | 6.1 | 836 | ||
| TP53 | R175H | 19 | 899 | TP53 | R175H | 8 | 840 | ||
| #34 | Colorectal cancer | KRAS | G12D | 33 | 769 | KRAS | G12D | 4.5 | 866 |
| TP53 | R175H | 29 | 879 | TP53 | R175H | 16 | 1119 | ||
| #35 | Lung adenocarcinoma | TP53 | G154V | 16 | 386 | TP53 | G154V | 4.6 | 1080 |
| #36 | Colorectal cancer | PIK3CA | H1074R | 56 | 819 | PIK3CA | H1074R | 40 | 1503 |
| TP53 | R175H | 57 | 205 | TP53 | R175H | 60 | 1287 | ||
| #37 | Renal cell cancer | TP53 | E285K | 51 | 226 | TP53 | E285K | 16.3 | 632 |
| #38 | Bladder cancer | PIK3CA | E545K | 56 | 2266 | PIK3CA | E545K | 9.4 | 1024 |
| TP53 | D281N | 44 | 950 | TP53 | D281N | 3.2 | 724 | ||
| TP53 | P278L | 44 | 951 | TP53 | P278L | ND | 732 | ||
| #39 | Ovarian cancer | CTNNB1 | S33C | 24 | 678 | CTNNB1 | S33C | ND | 1425 |
| PIK3CA | N345K | 41 | 946 | PIK3CA | N345K | 7.8 | 4139 | ||