Table 1.

Ongoing and planned demonstration PrEP (oral and topical) and open label extension projects involving women, men, MSM, sex worker and discordant couples

Study/project	Population	Description	Location	Status
Partners demonstration project	1000 HIV serodiscordant couples	Open label Daily truvada (TVD) oral as bridge to treatment in infected partner. F/up 24 months	Kenya, Uganda	Enrolling Results 2014/15
CAPRISA 008		Open label 1% TDF vaginal gel BAT 24	South Africa	Enrolling Results 2013
CHAMPS-SA PrEP	150 young men and women (15–19 yr)	Open label TVD oral	South Africa	Enrolling Results 2015/6
SAPPHIRE FSW RCT	2800 FSW	Open label Oral daily TVD	Zimbabwe	Enrolling
TAPs: Expanded use of ART for treatment and prevention for female sex workers in South Africa	400 FSW	Open label PrEP and immediate ART for FSWLWHIV	South Africa	Enrolling
Sibanye MSM Project	200 MSM	Open label (adult MSM)	South Africa	Enrolling Results 2015/6
PrEP for MSM	300 MSM	Open label (adult MSM)	South Africa	Under review
RCTS with planned open label extensions	Population	Description	Location	Status
ASPIRE	2629 hetero women	Placebo RCT Dapivirine vaginal ring	Zimbabwe, Malawi, Uganda, South Africa	Enrolling 2015
RING study	1959 hetero women	Placebo RCT Dapivirine vaginal ring	South Africa	Enrolling 2015