Table 1.

Experimental vaccine trials using a variety of antigen-preparation methods and their protection in fish following experimental infection

Antigens	Routes	Fish species	Challenge strains	RPS (%)	References
Formalin inactivated high pH Y. ruckeri O1, strain Y-11	Immersion	Rainbow trout	Y. ruckeri O1, strain Y-12	83–96	[89]
Yrp1 protease toxoid of Y. ruckeri, strain 150RI4	i.p.	Rainbow trout	Y. ruckeri, strain 150	79	[46]
Live attenuated Y. ruckeri O1, strain 21102	i.p.	Rainbow trout	Y. ruckeri O1, strain 21102	90	[94]
Formalin inactivated Y. ruckeri O1, biotype 1	Bath	Rainbow trout	Y. ruckeri O1, strain 392/2003	75–76.9	[61]
Extracellular product of Y. ruckeri	Immersion	Rainbow trout	Y. ruckeri	74–81.4	[95]
Formalin inactivated Y. ruckeri O1b biotype 1 (Yersinivac-B)	Immersion	Atlantic salmon	Y. ruckeri O1b, strain TCFB 2282	37	[91]
Trypsinated Yersinivac-B	Immersion	Atlantic salmon	Y. ruckeri O1b, strain TCFB 2282	55.6	[91]
Formalin inactivated Y. ruckeri serotype O1, biotype 1 × biotype 2 (EX5)	Immersion	Rainbow trout	Y. ruckeri O1, strains EX5, 58669, G1S1, DenA, BAS2A	87–100	[16]
Formalin inactivated Y. ruckeri serotype O1, biotype 1 × biotype 2 (EX5)	Immersion and i.p.	Rainbow trout	Y. ruckeri O1, biotype 2, strain 100415-1/4	100	[97]
Formalin inactivated Y. ruckeri biotype 1, strain Hagerman	Immersion	Rainbow trout	Y. ruckeri O1, biotype 2, strain 100415-1/4	29.5	[64]
Recombinant flagellin protein of Y. ruckeri biotype 1 BA19	i.p.	Rainbow trout	Y. ruckeri biotype 1 YR1 and biotype 2 R1	68–72	[99]
Formalin inactivated Y. ruckeri biotype 1, strain KC291153	Immersion with montanide adjuvant	Rainbow trout	Y. ruckeri biotype 1, strain KC291153	93.8–100	[82]
Lipopolysaccharide of Y. ruckeri	i.p.	Rainbow trout	Y. ruckeri	77.4–85.1	[94]
Formalin inactivated Y. ruckeri biotype 1, strain Hagerman	Oral and anal	Rainbow trout	Y. ruckeri O1, biotype 1, strain 392	100	[93]

i.pc intraperitoneal injection, RPS relative percentage survival.