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. 2015 Aug 5;16(8):18077–18095. doi: 10.3390/ijms160818077

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Screening test with 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. EC₅₀ (half maximal effective concentration) concentrations of doxorubicin, rituximab and vincristin of transfected RI-1 (left column) and SUDHL4 (right column) cells. Each bar represents the mean values of the EC₅₀ concentration in nM ± standard deviation of either miR-199a or miR-497 transfected cells or siRNA control, respectively. The comparison of the expression levels was performed by using the Mann–Whitney U test. * indicates reduced EC₅₀ concentration compared to siRNA (p < 0.05).