Table 3.
Univariate analysis of clinicopathological parameters for the prediction of overall survival (OS) and disease free survival (DFS) in our patient cohort (n = 58).
| Parameter | Univariate Analysis OS | Univariate Analysis DFS | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age at diagnosis (years) <65 ( n = 32) ≥65 (n = 26) |
1 (referent) 4.75 (1.54–14.59) |
0.003 | 1 (referent) 2.53 (1.09–5.87) |
0.03 |
| Clinical stage (Ann Arbor) I & II (n = 25) III & IV (n = 33) |
1 (referent) 2.84 (0.93–8.73) |
0.049 | 1 (referent) 3.24 (1.26–8.33) |
0.014 |
| R-IPI 1 + 2 (n = 36) 3 + 4 (n = 21) |
1 (referent) 8.6 (2.71–27.28) |
<0.001 | 1 (referent) 3.31 (1.42–7.74) |
0.006 |
| Subtype GCB + transformed DLBCL (n = 38) NGCB (n = 17) |
1 (referent) 6.31 (2.13–18.68) |
0.001 | 1 (referent) 2.5 (1.04–5.97) |
0.04 |
| miR-199a expression high (n = 29) low (n = 29) |
1 (referent) 0.24 (0.0–0.73) |
0.006 | 1 (referent) 0.47 (0.20–1.1) |
0.008 |
| miR-497 expression high (n = 29) low (n = 29) |
1 (referent) 0.36 (0.12–1.01) |
0.041 | 1 (referent) 0.63 (0.27–1.43) |
0.265 |
HR: hazard ratio; CI: confidence intervall; GCB: germinal center subtype; NGCB: non-germinal center subtype; R-IPI: revised International Prognostic Index; OS: overall survival; DFS: disease free survival.