Figure 1.

Effects of methotrexate (MTX) with/or without genistein on body weight gain. (A) Representative graph of weight accumulation over the period of treatment illustrating that MTX treatment (open circles, dashed line) slowed body weight gain, whilst the MTX and genistein combination (Gen/MTX, open square, dashed line) recovered their weight by the end of the trial; (B) Total body weight gained over the period of MTX administration until specimen collection. MTX significantly reduced weight accrual when compared to control group (** p < 0.01) or to the Gen alone group (^δ p < 0.001), and Gen supplementation (Gen/MTX) significantly attenuated the weight accrual suppression when compared to MTX alone group (^# p < 0.05) (n = 6).