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Role of Nrf2 in basal conditions to response as endogenous and exogenous stimulus (A) and in epilepsy state as consequences of kainic acid and pilocarpine-induced seizures as examined in human hippocampal tissue from resistant patients with temporal lobe epilepsy (B). Note that stabilization mechanisms have not yet been identified. In addition, antioxidants promote increased Nrf2 mRNA levels in the cell.
