Table 1.
Correlation between VM and clinicopathologic characteristics of colon cancer and expression of Wnt3a and β-catenin.
| Variable | Total (%) | Tissue Samples | χ2 | p Value | |||||
|---|---|---|---|---|---|---|---|---|---|
| VM (%) | nonVM (%) | ||||||||
| Age | |||||||||
| <45 | 28 (12.9) | 7 (25.0) | 21 (75.0) | 1.077 | 0.298 | ||||
| ≥45 | 189 (87.1) | 32 (16.9) | 157 (83.1) | ||||||
| Sex | |||||||||
| Male | 101 (46.5) | 19 (18.8) | 82 (81.2) | 0.09 | 0.86 | ||||
| Female | 116 (53.5) | 20 (17.2) | 96 (82.8) | ||||||
| Location | |||||||||
| Left hemicolon | 125 (57.6) | 25 (20.0) | 100 (80.0) | 0.475 | 0.822 | ||||
| Right hemicolon | 92 (42.4) | 14 (15.2) | 78 (84.8) | ||||||
| Tumor size(cm) | |||||||||
| ≥10 | 25 (11.5) | 6 (24) | 19 (76) | 0.70 | 0.278 | ||||
| <10 | 192 (88.5) | 33 (17.2) | 159 (82.8) | ||||||
| Histological differentiation | |||||||||
| Well differentiated | 14 (6.4) | 1 (7.1) | 13 (92.9) | 72.11 | <0.001 * | ||||
| Moderately differentiated | 109 (50.2) | 8 (7.3) | 101 (92.7) | ||||||
| Poorly differentiated | 53 (24.4) | 30 (56.6) | 23 (43.4) | ||||||
| Mucinous carcinoma | 41 (18.9) | 0 (0.0) | 41 (100.0) | ||||||
| TNM stage | |||||||||
| TNMⅠ | 10 (4.6) | 0 (0.0) | 10 (100.0) | 23.20 | <0.001 * | ||||
| TNMⅡ | 138 (63.6) | 16 (11.6) | 122 (88.4) | ||||||
| TNMⅢ | 57 (26.3) | 16 (28.1) | 41 (71.9) | ||||||
| TNMⅣ | 12 (5.5) | 7 (58.3) | 5 (41.7) | ||||||
| Metastasis/recurrence | |||||||||
| Present | 77 (35.5) | 24 (31.2) | 53 (68.8) | 14.099 | <0.001 * | ||||
| Abscent | 140 (64.5) | 15 (10.7) | 125 (89.3) | ||||||
| Wnt3a expression | |||||||||
| Negative | 22(10.1) | 0(0.0) | 22(12.4) | 17.7 | <0.001 * | ||||
| Weak expression | 97(44.7) | 10(34.5) | 87(48.9) | ||||||
| Strong expression | 98(45.2) | 29(65.5) | 69(38.7) | ||||||
| β-catenin expression | |||||||||
| Nuclear negative | 175 (80.6) | 18 (46.2) | 157 (88.2) | 36.2 | <0.001 * | ||||
| Nuclear positive | 42 (19.4) | 21 (53.8) | 21 (11.8) | ||||||
* Significantly different.