Table 1.
Active site residues for various transcarbamylases.
| Protein | CP-Binding Site | The Second Substrate-Binding Site |
|---|---|---|
| ATCase | S52, T53, R54, T55, R105 H134, Q137, P266, L267 Ser80 *, Lys84 * |
R167, Q231, R229, L267 |
| OTCase | S55, T56, R57, T58, R106 H133, Q136, C273, L274 R319, Q82 * |
N167, D231, S235, M236, L274 |
| PTCase | S52, T53, R54, T55, R103 H130, Q133, C269, L240 R297, Q79 * |
Q164, D227, Y233, L240 |
| AOTCase | S49, M50, R51, T52, R112 H148, Q151, C294, L295 R322, W77 * |
E144, K252, L295 |
| SOTCase | S47, L48, R49, T50, R110 H147, Q150, C274, L275 R302, W75 |
E142, K236, H176, R178, R278, L275 |
| YTCase | S71, T72, R73, T74, R122 H165, Q168, C330, L331 K363, Q98 * |
Q160, K270, D124, S200, K203, L331 |
| DPTCase | S50, T51, R52, T53, R100 H128, Q131, D250, L251 K278, Q76 * |
N159, T160, T211, R212, D250, L251 |
| DBTCase | S57, T58, R59, T60, R108 H135, Q138, D271, L272 K299, Q84 * |
N166, T229, S233, M234, L272 |
| UGTCase | S74, T75, R76, T77, R126 H155, Q158, T298, L299 S102 *, K106 * |
R189, S258, K261, T298, L299 |
* The residue is from the adjacent subunit. The residues in italics fonts indicate they are suggested substrate-binding residues that have not been confirmed by crystal structures.