Table 1.
Taxonomy and history of Borna disease virus (BDV) strains Hu-H1 and Strain V.
| Template | Hu-H1 (Abbreviation) | Strain V (Abbreviation) |
|---|---|---|
| Order | Mononegavirales | Mononegavirales |
| Family | Bornaviridae | Bornaviridae |
| Genus | Bornavirus | Bornavirus |
| Species | Borna disease virus (BDV) | BDV |
| Virus | BDV | BDV |
| Strain | BDV Hu-H1 (natural) | BDV Strain V (non-natural) |
| Isolation host | Homo sapiens (H. sapiens) | Equus ferus (E. ferus) |
| Isolation source | PBMCs | Brain |
| Sampling location | Germany (DEU), Berlin | Germany (DEU), Giessen |
| Sampling year | 1994 | 1927 |
| Genetic variant | Patient H1, female, 45 years., depressive episode, bipolar disorder (DSM IV 296.64), Berlin 1994, 3660-PBMC, passaged in human oligodendroglial (OL-221) cells (virus p11–p25), (stable virus titer from p11 on) | Horse V, fatal Borna disease (encephalomyelitis) (-hist), Giessen horse V brain, passaged in rabbits (brain, (20–50)×), rats (brain 6×), OL-221 cells (virus p10–p25) |
| Suffix | Passaged in OL cells (-tc) | Passaged in laboratory animal hosts and OL cells (-lab) |
| Pathology in rabbits | Behavioral disease (3 weeks p.i.), Hu-H1/OL p25 used | Fatal disease (3 weeks p.i.), Strain V/OL p12 used |
| GenBank accession No. | U58594, L76234, L76228, L76237 | U04608 (full-length) |
| Full designated name | Borna disease virus Hu-H1/H. sapiens-tc/DEU/1994/Berlin-Hu-H1-94 3660-PBMC | Borna disease virus Strain V/E. ferus VECTOR/O. cuniculus-lab/Wistar rat-lab/DEU/1927/Giessen-horse V-brain |
| Medium-length designation | BDV Hu-H1/Hsap-tc/DEU/94/Ber-Hu-H1-94 3660-PBMC | BDV Str. V/VECTOR/O. cun-lab/Wistar-lab/DEU/27/Gie-horse V-brain |
| Passage history of virus stock provided | OL-221/Hu-H1-94 3660, passage p75, 1994, provided 2010 to CQMU | OL-221/Strain V, passage p113, 1998, provided 2010 to CQMU |
| Passage grown at CQMU and used as virus source | OL-221/Hu-H1-94 3660, passage 77 in OL-221 passage 112 | OL-221/Strain V, passage 115 in OL-221 passage 116 |
BDV: Borna disease virus; PBMC: peripheral blood mononuclear cell; DEU: Germany; DSM: diagnostic and statistical manual of mental disorders; p.i.: post-infection; CQMU: Chongqing Medical University.