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. 2015 Aug 17;16(8):19347–19368. doi: 10.3390/ijms160819347

Table 3.

Key commonly altered metabolites detected by GC–MS for Hu-H1 and Strain V.

Hu-H1/Strain V Metabolite RT (min) MZ VIP-Value (OPLS-DA) p-Value (t-test) Hu-H1 Strain V Fold Change Hu-H1/CON Strain V/CON
Hu-H1 Strain V
1 Citric acid 14.63 273 2.42 1.66 1.10 × 10−10 4.82 × 10−16 −1.49 −3.22
2 l-CysteineL 11.61 218 1.86 1.44 0.000129 1.89 × 107 −1.34 −3.31
3 Pyruvic acid 5.05 174 2.19 1.09 4.58 × 107 4.94 × 105 −1.29 −2.4
4 l-Aspartic acid 11.2 233 2.14 1.52 0.00000144 1.61 × 108 −1.18 −2.06
5 Desmosterol 25.47 343 1.94 1.5 0.0000461 1.60 × 108 −1.16 −2.84
6 Margaric acid 17.6 117 2.35 1.42 3.73 × 109 4.04 × 107 −1.03 −0.97
7 Glycerol-3-phosphate 14.08 357 1.61 1.27 0.00167 3.36 × 105 −0.8 −1.28
8 l-Alanine 5.69 116 1.95 1.51 0.0000402 1.14 × 108 −0.67 −1.56
9 Myo-Inositol 17.38 305 1.87 1.41 0.000112 6.71 × 107 −0.66 −1.2
10 Serine 9.18 204 2.03 1.59 0.0000118 4.36 × 1011 −0.58 −1.7
11 Phenylalanine 12.43 218 1.16 1.38 0.0334 1.82 × 106 −0.56 −2.37
12 l-Threonine 9.54 218 1.84 1.55 0.000159 6.11 × 10−10 −0.53 −1.41
13 Pyroglutamic acid 11.19 156 1.27 1.15 0.018 3.22 × 104 −0.49 −0.91
14 Malic acid 10.82 233 1.31 1.38 1.46 × 102 1.44 × 106 −0.47 −1.64
15 l-Methionine 11.15 176 1.23 1.42 2.31 × 102 3.76 × 107 −0.46 −1.97
16 l-Proline 8.29 142 1.15 1.4 3.45 × 102 9.06 × 107 −0.31 −1.22
17 l-Valine 7.21 144 1.41 1.51 7.71 × 103 7.91 × 109 −0.24 −0.95
18 l-Leucine 7.97 158 1.24 1.46 2.22 × 102 9.99 × 108 −0.21 −0.91
19 l-Isoleucine 8.27 158 1.16 1.45 3.36 × 102 1.34 × 107 −0.2 −0.78
20 Eicosanoic acid 20.1 117 1.17 1.02 3.19 × 102 1.95 × 103 0.27 0.45
21 Ethanolamine 7.9 174 1.35 1 1.13 × 102 2.52 × 103 0.77 0.77
22 Methylsuccinic acid 8.69 261 1.86 1.25 1.42 × 104 0.0000518 1.79 1.64