Table 1.
At-baseline comparisons between demographic and clinical characteristics of factor XIII-A 185-T-allele carriers (patients with GT or TT polymorphic genotypes) and non-carriers (patients with wild-GG genotype).
| Study Population (n = 412 Patients Affected by Subfoveal CNV) | |||||
|---|---|---|---|---|---|
| Baseline Characteristics | FXIII-A 185-T-Allele Carriers (n = 187) | FXIII-A 185-T-Allele Non-Carriers (n = 225) | p Value | ||
| Sex | |||||
| Male/Female–no. (%) | 86 (46.0)/101 (54.0) | 104 (46.2)/121 (53.8) | NS * | ||
| Mean age ± SD (range)–years | 64.514 ± 13.807 (34–86) | 64.802 ± 15.122 (33–88) | NS † | ||
| Mean BCVA ± SD (range)–logMAR | 0.604 ± 0.215 (0.2–1.0) | 0.594 ± 0.231 (0.1–1.0) | NS † | ||
| Mean CNV area ± SD (range)–micron2 | 2894.2 ± 2789.3 (232–10,065) | 2759.4 ± 2605.7 (244–10,125) | NS † | ||
| Type of neovascular lesion | |||||
| Classic or predominantly classic AMD-related CNV–no. (%) | 63 (33.7) | 76 (33.8) | NS * | ||
| Minimally classic or occult AMD-related CNV–no. (%) | 48 (25.7) | 57 (25.3) | NS * | ||
| Classic PM-related CNV–no. (%) | 76 (40.6) | 92 (40.9) | NS * | ||
Legend: CNV, choroidal neovascularization; FXIII, factor XIII; SD, standard deviation; BCVA, best-correct visual acuity; logMAR, logarithm of the minimum angle of resolution; AMD, age-related macular degeneration; PM, pathologic myopia; *, χ2 test; †, two-sided t-test; NS, not significant.