Table 2.

Tumor suppressive miRNAs in CRC.

Names	Expression	Targets	Biological Events	References
miR-18a	-	K-Ras	cell proliferation, anchorage-independent growth	[42]
miR-100	↓	RAP1B	cell proliferation, invasion, apoptosis	[54]
miR-124	↓	STAT3	cell proliferation, apoptosis, tumor growth, differentiation, prognosis	[55,56]
miR-126	↓	IRS-1, VEGF, CXCR4	cells proliferation, migration, invasion, cell cycle arrest, angiogenesis, diagnosis	[50,51,52,53]
miR-133a	↓	FSCN1, LASP1	cell proliferation, invasion, migration, tumor growth, intrahepatic and pulmonary metastasis, phosphorylation of ERK/MEK	[43,44]
miR-133b	↓	TBPL1, CXCR4	cell proliferation, invasion, migration, apoptosis	[45,46]
miR-139	↓	IGF-IR, NOTCH1	cell proliferation, migration, invasion, apoptosis, tumor growth, cell cycle arrest	[57,58]
miR-145	↓	Fascin-1	cell proliferation, invasion, tumor growth, pulmonary metastasis	[59]
miR-148b	↓	CCK2R	cell proliferation, tumor growth, tumor size	[60]
miR-194	↓	PDK1, AKT2, XIAP, MAP4K4	cell proliferation, apoptosis, migration, invasion, cell cycle arrest, tumor growth, tumor size, differentiation, TNM stage, lymph node metastasis, prognosis	[47,48]
miR-206	↓	NOTCH3	cell proliferation, migration, apoptosis, cell cycle arrest	[61]
miR-214	↓	FGFR1	cell proliferation, migration, invasion, tumor growth, liver metastasis	[62]
miR-218	↓	BMI-1	cell proliferation, apoptosis, cell cycle arrest	[63]
miR-224	↓	Cdc42	cell migration	[64]
miR-320a	↓	β-catenin, Rac1	cell proliferation, migration, invasion, cell cycle arrest	[65,66]
miR-342	↓	DNMT1	cell proliferation, invasion, cell cycle arrest, tumor growth, lung metastasis	[67]
miR-375	↓	PIK3CA	cell proliferation, cell cycle arrest, tumor growth	[68]
miR-378	↓	vimentin	cell proliferation, invasion, tumor growth, tumor size, lymph node metastasis, clinical stage, prognosis	[69]
miR-429	↓	Onecut2	cell migration, invasion, EMT	[70]
miR-455	↓	RAF1	cell proliferation, invasion	[71]
miR-638	↓	SOX2	cell invasion, migration, EMT	[72]

↓: downregulated; -: unknown.