Table 5.
Other significant lncRNAs in CRC.
| Names | Location | Expression | Biological Events | Putative Roles | References |
|---|---|---|---|---|---|
| LOC285194 | Chr3q13.31 | ↓ | tumor size, TNM stage, distant metastasis, prognosis, p53 transcription target, repression of miR-211, cell growth | diagnostic and prognostic biomarker | [153,154] |
| uc.73 | Chr2q22.3 | ↓ | overall survival | diagnostic and prognostic biomarker | [155] |
| uc.388 | Chr12q13.13 | ↓ | distal location of CRC | diagnostic and prognostic biomarker | [155] |
| lincRNA-p21 | Chr6p21.2 | ↓ | higher expression in rectum, stage III tumors, pT and vascular invasion, sensitivity of radiotherapy by targeting the Wnt/β-catenin signaling pathway, cell apoptosis, promote pro-apoptosis gene Noxa expression | sensitivity of CRC radiotherapy | [156,157] |
| GAS5 | Chr1q25.1 | ↓ | tumor size, histological grade, TNM stage, prognosis, cell proliferation | prognostic biomarker | [158] |
| ncRAN | Chr17q25.1 | ↓ | histological grade, tumors with liver metastases, prognosis, cell migration, invasion | diagnostic and prognostic biomarker | [159] |
| ncRuPAR | Chr5q13.3 | ↓ | lymph node metastasis, distant metastasis, Duck’s stage, histological grade, TNM stage, negatively associated with PAR-1 | diagnostic biomarker | [160] |
| MEG3 | Chr14q32.2 | ↓ | histological grade, tumor invasion, TNM stage, prognosis, cell proliferation | diagnostic and prognostic biomarker | [161] |
| RP11-462C24.1 | Chr4q25 | ↓ | distant metastasis, prognosis | prognostic biomarker | [162] |
| PRNCR1 | Chr8q24.21 | - | SNPs in PRNCR1 may be involved in the risk of CRC (rs13252298, rs1456315, rs7007694, rs16901946 and rs1456315) | - | [163] |
| PVT-1 | Chr8q24.21 | ↑ | cell proliferation, invasion, apoptosis, prognosis | prognostic biomarker | [164] |
| CRNDE | Chr16q12.2 | ↑ (tissue and plasma) | regulating cellular metabolism by insulin/IGFs, a downstream target of the PI3K/Akt/mTOR pathway or Raf/MAPK pathway | diagnostic biomarker | [165,166] |
| HULC | Chr6p24.3 | ↑ (colorectal hepatic metastasis) | neither expressed in primary CRC samples nor normal tissues but upregulated in colorectal hepatic metastasis | - | [167] |
| PCAT-1 | Chr8q24.21 | ↑ | distant metastasis, prognosis | prognostic biomarker | [168] |
| BANCR | Chr9 | ↑ or ↓ | lymph node metastasis, tumor stage, contribute to cell migration by inducing EMT via an MEK/ERK-dependent mechanism, cell proliferation, apoptosis, G0/G1 cell cycle arrest, targeting p21 | therapeutic application | [169,170] |
| UCA1 | Chr19p13.12 | ↑ | cell proliferation, apoptosis, cell cycle, tumor size, histological grade, tumor depth, prognosis | diagnostic and prognostic biomarker | [171] |
| ATB | Chr14 | - | tumor size, tumor depth, lymphatic invasion, vascular invasion, lymph node metastasis, hematogenous metastases, prognosis | prognostic biomarker | [172] |
| LINC01296 | Chr14q11.2 | ↑ | prognosis | prognostic biomarker | [173] |
| CCAL | - | ↑ | promoting CRC progression and induced multidrug resistance by targeting activator protein 2α, shorter overall survival, worse response to adjuvant chemotherapy | therapeutic application | [174] |
↑: upregulated; ↓: downregulated; -: unknown.