Table 1.
Positive associations of SNPs in miRNA genes with MS risk †.
| Carriage of Allele/Genotype Combinations | Carriers (%)/Noncarriers (%) | Fisher’s pf-Value | Bonferroni-Corrected ‡ pcorr-Value | OR (95% CI) | |
|---|---|---|---|---|---|
| - | Without Gender Stratification | - | |||
| MS Cases, n = 561 | Controls, n = 441 | ||||
| MIR223*T # | 155 (27.6)/406 (72.4) | 86 (19.5)/355 (80.5) | 0.0017 | 0.0068 | 1.58 (1.17–2.13) |
| MIR146A*G/G | 359 (64.0)/202 (36.0) | 268 (60.8)/173 (39.2) | 0.16 | 0.64 | 1.15 (0.89–1.48) |
| MIR223*T + MIR146A*G/G | 103 (18.4)/458 (81.6) | 55 (12.5)/386 (87.5) | 0.0068 | 0.041 | 1.58 (1.11–2.25) |
| - | Women | - | |||
| MS Cases, n = 395 | Controls, n = 285 | ||||
| MIR223*T | 122 (30.9)/273 (69.1) | 65 (22.8)/220 (77.2) | 0.012 | 0.048 | 1.51 (1.07–2.15) |
| MIR146A*G/G | 259 (65.6)/136 (34.4) | 165 (57.9)/120 (42.1) | 0.025 | 0.10 | 1.39 (1.01–1.90) |
| MIR223*T + MIR146A*G/G | 83 (21.0)/312 (79.0) | 37 (13.0)/248 (87.0) | 0.0042 | 0.025 | 1.79 (1.17–2.72) |
| - | Men | - | |||
| MS Cases, n = 166 | Controls, n = 149 | ||||
| MIR223*T | 33 (19.9)/130 (80.1) | 21 (14.1)/128 (85.9) | 0.11 | 0.44 | 1.51 (0.83–2.75) |
| MIR146A*G/G | 100 (60.3)/66 (39.7) | 98 (65.8)/51 (34.2) | 0.19 | 0.76 | 0.79 (0.50–1.25) |
| MIR223*T + MIR146A*G/G | 20 (12.0)/146 (88.0) | 18 (12.1)/131 (87.9) | 0.56 | 1.00 | 1.00 (0.51–1.97) |
† Only data for the SNPs, which were significantly associated with MS at least at one of the comparisons, are presented above. Allele/genotype carriage frequencies for all genes are presented in Table S2; ‡ p-values were corrected for 4 independent comparisons in case of single alleles/genotypes carriage and for 6 independent comparisons in case of biallelic combinations; # Hereinafter an allele carriage rate is calculated as a sum of homozygous and heterozygous genotypes containing this allele. Significant pf and pcorr-values are in bold; OR—odds ratio; CI—confidential interval.