Table 2.

P values, q values, and fold differences of metabolites observed to be statistically significantly different between HCC cases (n = 114) and matched controls (n = 222)

	HCC cases vs. matched controls
Metabolites	P valuea	q valueb	Fold difference
Lipids = CH-CH 2-CH=	9 × 10-11	3 × 10-08	0.84
N-acetyl glycoproteins	3 × 10-10	4 × 10-08	0.90
Unspecificc,d	4 × 10-10	4 × 10-08	0.82
Glutamate	4 × 10-09	3 × 10-07	1.22
Tyrosine	1 × 10-08	7 × 10-07	1.24
Choline	2 × 10-08	7 × 10-07	0.82
Lipids O-CH 2	1 × 10-07	3 × 10-06	0.84
Phenylalanine	2 × 10-07	5 × 10-06	1.23
Unspecificc,e	4 × 10-07	9 × 10-06	0.84
Leucine	2 × 10-06	3 × 10-05	0.91
Lipids CH 2-CH2-COOC	2 × 10-06	3 × 10-05	0.82
Unsaturated lipidsf	2 × 10-06	3 × 10-05	0.86
Isoleucine	2 × 10-05	2 × 10-04	0.90
Lipids CH 2-CH=	2 × 10-05	2 × 10-04	0.94
CH 3 bond of lipids (VLDL)g	2 × 10-05	2 × 10-04	0.87
Propylene glycol	7 × 10-05	6 × 10-04	1.45
Lipids (CH 2)n	1 × 10-04	8 × 10-04	0.88
Ethanol	3 × 10-04	2 × 10-03	1.65
Glutamine	7 × 10-04	4 × 10-03	0.90
Glucose	8 × 10-04	4 × 10-03	1.10
Valine	3 × 10-03	1 × 10-02	0.93
Acetate	5 × 10-03	2 × 10-02	1.24
Citrate	1 × 10-02	4 × 10-02	1.08

^a P value was obtained from ANOVA mixed-effects models

^b q value corresponds to the value obtained after Benjamini-Hochberg correction for multiple testing

^cMultiple assignments for the same cluster of variables due to spectral overlap

^dAcetone and CH₂-CH ₂-COOC of bound lipids

^eMannose and glyceride of lipids

^fUnsaturated lipids as estimated from the CH = CH signal of lipids

^gPart of terminal lipids methyl signal corresponding to VLDLs