(a).

Subjects	Demographic and clinical characteristics of subjects with CSF leakage
	Age (years)	Gender	BMI	Relevant comorbidities	Symptoms	Orthostatic symptoms	DD (days)	Prior traumatic event	Other events before disease onset
1	50	f	24.7	None	Headache left frontal	Yes	30	No	Physical exertion
2	40	f	18.4	Marfan's syndrome, Arnold-Chiari I malformation, and depressive disorder	Occipital and temporal headache	Yes	14	No	No
3	43	m	26	None	Occipital headache	Yes	10	No	No
4	45	f	23.7	Migraine with aura	Occipital headache, pressure feeling in left ear, diplopia, and paresthesia in left arm and leg	Yes	173	No	No
5	72	f	14.7	Subtotal colectomy, short bowel syndrome, cachexia, chronic gastritis, and numerous intestinal operations due to recurrent ileus	Occipital headache, vertigo	Yes	360	No	No
6	30	f	21.5	None	Holocephalic headache	Yes	30	No	No
7	44	m	25.2	Arterial hypertension	Holocephalic headache, vertigo, vomiting, diplopia, and paresthesia in left arm and leg	Yes	196	Fenestration of a spinal arachnoid cyst T2–4	Decompression surgery due to disc herniation at the level of C5/6
8	23	f	22.8	None	Occipital headache, vertigo, and photosensitivity	Yes	4	No	No
9	44	f	20.2	None	Occipital headache, vertigo, vomiting, and abducens nerve palsy	Yes	2	No	No
10	52	f	23.4	Cervical conisation due to cervix carcinoma and decompression surgery due to disc herniation at the level of L5/S1	Holocephalic headache	Protracted	202	No	No