Table 3.
Outcome of patients according to Siewert classification.
| Outcome | Siewert 1 | Siewert 2 | Siewert 3 | Siewert 2 + 3 |
Siewert 1 versus 2 versus 3 p |
Siewert 1 versus (2 + 3) p |
|---|---|---|---|---|---|---|
| Mean | ||||||
| OS ± SE (months) | 70 ± 11.7 | 53.2 ± 7.2 | 61.3 ± 18.8 | 56.7 ± 7.2 | 0.18 | 0.14 |
| Mean | ||||||
| ORR ± SE (%) | 27.3 ± 13.4 | 76.5 ± 8.3 | 20 ± 17.9 | 62 ± 7.9 | 0.052 | 0.047 |
| Mean | ||||||
| CRLR ± SE (%) | 19.2 ± 10.1 | 41.8 ± 10.1 | 0 | 37.5 ± 9.2 | 0.27 | 0.35 |
| Mean | ||||||
| CRNR ± SE (%) | 0 | 45.1 ± 10.7 | 20 ± 17.9 | 41.3 ± 9.7 | 0.08 | 0.028 |
| Mean | ||||||
| CRMR ± SE (%) | 9.1 ± 8.7 | 65.2 ± 9.7 | 75 ± 21.7 | 60.2 ± 8.9 | 0.017 | 0.012 |
| pCR, n (%) | ||||||
| Yes | 6 (40) | 8 (21.1) | 2 (40) | 10 (23.3) | 0.31 | 0.21 |
| No | 9 (60) | 30 (78.9) | 3 (60) | 33 (76.7) | ||
| NA (n = 10) | ||||||
| Cause of death, n (%) | ||||||
| Disease progression | 2 (33.3) | 25 (78.1) | 1 (50) | 26 (76.5) | 0.09 | 0.06 |
| Complication | 3 (50) | 3 (9.4) | 1 (50) | 4 (11.8) | ||
| Other causes | 1 (16.7) | 4 (12.5) | 0 | 4 (11.8) | ||
| Cause of death, n (%) | ||||||
| Disease progression | 2 (33.3) | 25 (78.1) | 1 (50) | 26 (76.5) | 0.07 | 0.03 |
| Other causes | 4 (66.7) | 7 (21.9) | 1 (50) | 8 (23.5) |
OS: overall survival; ORR: overall relapse rate; SE: standard error; CRLR: cumulative rate of local relapse; CRNR: cumulative rate of nodal relapse; CRMR: cumulative rate of metastatic relapse; pCR: pathological complete response; NA: nonavailable.