Table 1.
Time evolution of demographic characteristics in 1784 transplantations performed from 1983 to 2014.
| Transplant years | 1983–1991 | 1992–1997 | 1998–2003 | 2004–2009 | 2010–2014 | P value | Number of missing values | ||
|---|---|---|---|---|---|---|---|---|---|
| Number of grafts | 421 | 385 | 346 | 353 | 279 | <1998 | ≥1998 | ||
|
| |||||||||
| Recipient | Male gender | 60.8 | 61.8 | 61.9 | 62.9 | 62.0 | 0.99 | ||
| Age (y) | 35.8 ± 9.7 | 39.1 ± 11.1 | 46.7 ± 12.4 | 50.6 ± 12.4 | 53.1 ± 12.8 | <0.001 | |||
| Regrafting | 20.2 | 17.1 | 26.3 | 13.6 | 15.1 | <0.001 | |||
| Duration of regular dialysis (y) | 3.5 ± 3.0 | 3.7 ± 3.0 | 4.1 ± 4.6 | 3.1 ± 2.9 | 3.5 ± 3.1 | 0.007 | |||
| History of diabetes | 1.1 | 0 | 4.0 | 11.9 | 15.1 | <0.001 | |||
| History of cardiovascular disease | 4.8 | 6.5 | 10.4 | 22.4 | 13.6 | <0.001 | |||
| Peak (>50% PRA) sensitization | 20.7 | 6.8 | 9.2 | 8.2 | 6.1 | <0.001 | |||
| Delayed graft function (DGF) | 48.7 | 17.7 | 16.5 | 11.0 | 4.7 | <0.001 | |||
| Perioperative saline loading | 0 | 100 | 100 | 100 | 100 | <0.001 | |||
| Use of mycophenolate mofetil | 0 | 4.9 | 83.5 | 92.1 | 98.9 | <0.001 | |||
| Immunoglobulin induction | 56.5 | 95.3 | 78.6 | 92.9 | 98.9 | <0.001 | |||
| ARE occurring during DGF period | 27.3 | 10.7 | 5.8 | 6.3 | 3.6 | <0.001 | |||
| Biopsy proven | 79.8 | 90.4 | 94.2 | 94.6 | 96.8 | <0.001 | |||
| Residual diuresis (<500 mL/24 h) | 69.0 | 66.5 | 64.5 | 51.3 | 52.3 | <0.001 | 267 | 127 | |
| BMI (kg/m2) | 22.7 ± 3.8 | 23.9 ± 3.6 | 24.5 ± 4.3 | 25.2 ± 4.7 | 25.3 ± 4.8 | <0.001 | 271 | 126 | |
|
| |||||||||
| Donor | Male gender | 60.9 | 62.2 | 59.5 | 58.4 | 50.5 | 0.024 | ||
| Age (y) | 52.4 ± 14.3 | 37.5 ± 14.4 | 42.7 ± 16.0 | 44.0 ± 15.1 | 48.8 ± 13.0 | <0.001 | |||
| Donation after cardiac death | 0 | 0 | 1.2 | 2.7 | 13.6 | <0.001 | |||
| Traumatic cause of death | 57.9 | 45.7 | 40.8 | 34.9 | 27.2 | <0.001 | 11 | 8 | |
| Terminal serum creatinine (mg/dL) | 1.00 ± 0.39 | 0.95 ± 0.36 | 0.91 ± 0.33 | 0.77 ± 0.31 | 0.70 ± 0.25 | <0.001 | 43 | 51 | |
| BMI (kg/m2) | 23.2 ± 4.0 | 23.7 ± 3.5 | 24.7 ± 4.2 | 24.9 ± 4.6 | 25.6 ± 4.3 | <0.001 | 132 | 131 | |
|
| |||||||||
| Transplant | Ischaemia times | ||||||||
| Cold (h) | 27.3 ± 7.6 | 22.8 ± 6.2 | 18.8 ± 6.0 | 17.2 ± 5.0 | 16.3 ± 5.5 | <0.001 | 0 | 2 | |
| Warm (min) | 34.2 ± 7.9 | 33.0 ± 7.8 | 33.2 ± 8.3 | 30.0 ± 7.5 | 32.6 ± 9.0 | <0.001 | 0 | 2 | |
| Number of HLA-A+B+DR mismatches | 2.6 ± 1.5 | 2.2 ± 1.3 | 2.7 ± 1.3 | 2.5 ± 1.2 | 2.6 ± 1.1 | <0.001 | |||
Nominal variables are expressed as percent of total grafts and numerical variables as mean ± standard deviation.
PRA: panel reactive antibodies; ARE: acute rejection episode; BMI: body mass index.