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. 2015 Jul 30;24(20):5930–5939. doi: 10.1093/hmg/ddv293

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© The Author 2015. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Manhattan and QQ plots. Manhattan plots with markers P < 1.E − 5 in green and P < 5.E − 8 in red indicate a strong signal on chromosome 6. QQ plots of test statistics show inflation of associations at lower P-values. A grey line indicates a straight line relationship. The genomic inflation factor (λ) is shown in text above the QQ plot. Removal of the extended MHC region resulted in a genomic inflation factor of 1.007. A dashed line indicates P = 5.E − 8.