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Tet2 inhibition reduces 5hmC levels and increased infarct volume after MCAO. (A) The mice were administered (i.c.v.) with the Tet2 inhibitor SC1 30 min before MCAO. Dot blot analysis was performed with anti-5hmC in ischemic tissues. (B) SC1 pre-treatment increased infarct volume after MCAO. (C) Tet2 KO increased infarct volume after MCAO. Representative TTC-stained coronal sections are shown. *P < 0.05.
