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. 2015 Jul 30;24(20):5855–5866. doi: 10.1093/hmg/ddv307

Figure 6.

Figure 6.

Ischemic injury increased both 5hmC level at the BDNF promoter region and BDNF expression. (A) Differential 5hmC distributions on the BDNF gene were shown in the IGV browser. (B) BDNF mRNA increased after cerebral I/R injury. (C) When the mice were treated with the Tet2 inhibitor SC1, SC1 decreased BDNF mRNA after cerebral I/R injury. GAPDH was used as a loading control. (D) Representative graph of BDNF proteins is shown. SC1 treatment reduced BDNF expression after cerebral I/R injury. Beta-tubulin was used as a loading control. Versus sham group, *P < 0.05 and versus I/R group, ##P < 0.05.