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. 2015 Aug 5;24(20):5891–5900. doi: 10.1093/hmg/ddv312

Figure 3.

Figure 3.

LM-γ2 functional significance. Inhibition of LM-γ2 (A) reduced cell invasion (B) and Src activity (C). (D) LM-γ2 induces resistance to apoptosis, as evidenced by a decrease in Caspase-3 levels in control cells when compared with those transfected with siRNA for LM-γ2. (E) pJNK underexpression and (F) pAkt upregulation in gastric cancer cells expressing LM-γ2 suggest that they are involved in the control of survival. Graphs correspond to protein expression levels obtained by band quantification or percentage of invasive cells. Values were normalized to tubulin and AGS parental cells transfected with non-targeting control siRNA (AGS siCtr). For the experiment in which apoptosis was stimulated, values were normalized by AGS siCtr treated with DMSO. Average ± SE is presented. (*) represents a significant difference of P ≤ 0.05, (**) of P ≤ 0.01 and (***) of P ≤ 0.001.