Table 1. General information about gene expression of paired or unpaired mature females exposed to PZQ compared with no-drug controls.

S. mansoni genes	Expressed genes a	Paired Females			Unpaired Mature Females
		Diff. expressed b	Down-regulated	Up-regulated	Diff. expressed b	Down-regulated	Up-regulated
Detected on the microarrays	8,180	486	10	476	1,434	1,109	325
Predicted in the genome	5,903	351	4	347	1,005	809	196
Not predicted in the genome c	2,277	135	6	129	429	300	129

^a Number of genes expressed in at least one condition, i.e. in no-drug control or in treated worms of either the paired or the unpaired worm groups.

^b q-value < 5%

^c Either predicted in S. japonicum, present in other species, or detected only in S. mansoni without close homologs in other species (no match).