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. 2015 Sep 24;11(9):e1005513. doi: 10.1371/journal.pgen.1005513

Fig 4. ETHR expression levels affect timing of calcium mobilization in CAMB neurons.

Fig 4

(A) Changes in timing of calcium mobilization in CAMB neurons caused by manipulation of ETHR expression. Latency to onset of calcium mobilization in ETHR-RNAi knockdown preparations (ETHR-KD) is delayed in excess of 40 min. Conversely, onset timing of calcium mobilization is accelerated as a consequence of ETHR overexpression (ETHR-OE). (B) Over-expression of ETH receptor increased spontaneous responses in the neurons in absence of ETH. Under conditions of ETHR knockdown, no spontaneous response was observed.