Table 2. Estimated family-wise error rate for all methods under different null models, using a significance threshold of 0.05.

Model 1	Adaptive	Static	Logistic	Marginal+logistic	CSS+logistic	R2+logistic	LD-contrast	Sixpac	MB-MDR
No association	0.005	0.005	0.005	0.015	0.02	0.015	0.045	0.005	0.015
Single 2	0	0	0.02	0.015	0.025	0.05	0.045	0.005	0.02
Double 3 :identity	0.02	0.025	0.275	0.355	0.145	0.075	0.08	0.22	0.31
Double:log	0.01	0.01	0.025	0.035	0.035	0.035	0.03	0.01	0.035
Double:odds	0.035	0.02	0.955	0.975	0.54	0.16	0.66	0.985	0.99
Double:logit	0.015	0.015	0.04	0.03	0.035	0.07	0.035	0.005	0.035
Double:log-compl	0.03	0.025	0.03	0.045	0.035	0.035	0.03	0.01	0.04
Multi 4 :10	0.15	0.015	0.035	0.03	0.025	0.05	0.055	0.015	0.06
Multi:20	0.145	0.015	0.025	0.05	0.025	0.07	0.055	0.005	0.055
Multi:30	0.135	0.035	0.01	0.03	0.03	0.025	0.045	0	0.015

¹ Model from which data was generated

² Single main association

³ Double main association

⁴ Multivariate additive GLM