Table IV.
Top three function enrichment terms of genes in the interaction network of differentially expressed genes.
| Category | Term | Count | P-value | Fold-enrichment | FDR |
|---|---|---|---|---|---|
| Pre-summation | |||||
| BP | GO:0006355~regulation of transcription, DNA-dependent | 18 | 9.29E-16 | 7.630006 | 1.24E-12 |
| BP | GO:0051252~regulation of RNA metabolic process | 18 | 1.36E-15 | 7.461666 | 1.87E-12 |
| BP | GO:0045449~regulation of transcription | 18 | 6.43E-13 | 5.201077 | 8.98E-10 |
| CC | GO:0031981~nuclear lumen | 11 | 1.83E-08 | 7.458992 | 1.46E-05 |
| CC | GO:0070013~intracellular organelle lumen | 11 | 1.35E-07 | 6.079561 | 1.08E-04 |
| CC | GO:0043233~organelle lumen | 11 | 1.68E-07 | 5.942604 | 1.35E-04 |
| MF | GO:0043565~sequence-specific DNA binding | 18 | 1.96E-23 | 21.3888 | 1.89E-20 |
| MF | GO:0046983~protein dimerization activity | 17 | 1.12E-21 | 22.6231 | 1.08E-18 |
| MF | GO:0003700~transcription factor activity | 18 | 6.75E-20 | 13.3159 | 6.50E-17 |
| Post-summation | |||||
| BP | GO:0006355~regulation of transcription, DNA-dependent | 12 | 1.91E-10 | 7.630006 | 2.53E-07 |
| BP | GO:0051252~regulation of RNA metabolic process | 12 | 2.44E-10 | 7.461666 | 3.23E-07 |
| BP | GO:0006350~transcription | 12 | 1.24E-09 | 6.438839 | 1.64E-06 |
| CC | GO:0031981~nuclear lumen | 7 | 1.33E-05 | 7.713276 | 1.06E-02 |
| CC | GO:0070013~intracellular organelle lumen | 7 | 4.45E-05 | 6.286818 | 3.53E-02 |
| CC | GO:0043233~organelle lumen | 7 | 5.09E-05 | 6.145192 | 4.03E-02 |
| MF | GO:0046983~protein dimerization activity | 12 | 6.09E-16 | 23.95387 | 5.00E-13 |
| MF | GO:0043565~sequence-specific DNA binding | 12 | 2.14E-15 | 21.3888 | 1.88E-12 |
| MF | GO:0003700~transcription factor activity | 12 | 4.07E-13 | 13.3159 | 3.63E-10 |
Top three BP, CC and MF terms, were determined based on the lowest P-values. BP, biological process; CC, cellular component; MF, molecular function; FDR, false discovery rate.