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. 2015 Jul 7;12(4):5019–5025. doi: 10.3892/mmr.2015.4052

Figure 2.

Figure 2

Expression levels of miR-197 affect the sensitivity of SGC7901 cells to 5-FU. (A) Following transfection with anti-miR-197, the expression levels of miR-197 were significantly reduced in SGC7901 cells. (B) Following transfection with anti-miR-197 or control, SGC7901 cells were treated with various doses of 5-FU (0.5, 1.0, 2.0, 4.0 or 8.0 µmol/l) for 48 h. An MTT assay was performed to determine the cell growth inhibition. (C) Following transfection of the miR-197 mimics, the expression levels of miR-197 were significantly increased in SGC7901/5-FU cells. (D) Following transfection with the miR-197 mimics or control, the SGC7901/5-FU cells were treated with various doses of 5-FU (0.5, 1.0, 2.0, 4.0 and 8.0 µmol/l) for 48 h. The MTT assay was performed to determine the cell growth inhibition. Values are expressed as the mean ± standard deviation (n=3). *P<0.05 vs. control. miR-197, microRNA-197; 5-FU, fluorouracil; SGC7901/5-FU, SGC7901 cell line resistant to 5-FU.