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. 2015 Jul 2;12(4):4939–4946. doi: 10.3892/mmr.2015.4021

Figure 4.

Figure 4

Immunohistochemistry for GKRP in the CA1 region of the (A–D) ischemia and (E–H) IPC + ischemia groups following sham surgery and 1, 2 and 5 days post-ischemia-reperfusion. GKRP immunoreactivity was readily detected in the SP in the sham-group. GKRP immunoreactivity in the SP was marginally decreased 2 days after ischemia-reperfusion. At 5 days post-ischemia, GKRP immunoreactivity was almost undetectable in the SP. At 5 days post- ischemia-reperfusion, marked GKRP immunoreactivity was observed in non-pyramidal cells (arrows) of the SO and SR. In the IPC + sham and IPC + ischemia groups, GKRP immunoreactivity was similar to that in the sham group. Scale Bar=50 µm. GKRP, glucokinase regulatory protein; IPC, ischemic preconditioning; SP, stratum pyramidale; SO; stratum oriens, SR; stratum radiatum.