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. Author manuscript; available in PMC: 2015 Sep 24.
Published in final edited form as: Clin Immunol. 2011 Feb 26;139(3):302–313. doi: 10.1016/j.clim.2011.02.014

Figure 6.

Figure 6

Impact of PD-L1 and CTLA-4 blockade on CD8 T-cell proliferation and cytokine production by intracellular staining. A. The frequency of proliferated (CFSElo) TNFα−IFNγ− per CD8+ T-cell in presence of control Ig versus anti-PD-L1 and anti-CTLA-4 mAbs for 7 individual patients. B. Percentage of IFNγ+ (left) and TNFα+ (right) T-cells per CD4+ cells in presence of control Ig versus anti-PD-L1 and anti-CTLA-4 mAbs (p by matched pair analysis). C. Example of effect on expansion and cytokine production of pentamer-specific CD8+ T-cells in presence of control Ig, anti-PD-L1 and anti-CTLA-4 mAbs for four glypican-3 pentamers.