Table 3.
Estimated effects (β)* of the MIND diet score on the rate of change in global cognitive score and change in five cognitive domains among MAP participants over an average 4.7 years of follow-up in adjusted* mixed models
| Global | Episodica | Semanticb | Perceptualc | Perceptuald | Workinge | ||
|---|---|---|---|---|---|---|---|
| Cognition | Memory | Memory | Organization | Speed | Memory | ||
| Age-Adjusted | n** | 960 | 949 | 945 | 932 | 934 | 957 |
| β | 0.0090 | 0.0079 | 0.0069 | 0.0057 | 0.0088 | 0.0049 | |
| Standard Error | (0.0023) | (0.0027) | (0.0026) | (0.0025) | (0.0024) | (0.0024) | |
| P-Value | 0.0001 | 0.003 | 0.007 | 0.02 | 0.0002 | 0.04 | |
| Basic† | n** | 818 | 808 | 804 | 793 | 794 | 816 |
| β | 0.0095 | 0.0080 | 0.0105 | 0.0077 | 0.0084 | 0.0050 | |
| Standard Error | (0.0023) | (0.0028) | (0.0027) | (0.0025) | (0.0024) | (0.0024) | |
| P-Value | <0.0001 | 0.004 | 0.0001 | 0.002 | 0.0003 | 0.04 | |
| Basic + | |||||||
| Cardiovascular | |||||||
| Conditions ± | n** | 860 | 850 | 846 | 835 | 836 | 858 |
| β | 0.0106 | 0.0090 | 0.0113 | 0.0077 | 0.0097 | 0.0060 | |
| Standard Error | (0.0023) | (0.0028) | (0.0027) | (0.0025) | (0.0023) | (0.0024) | |
| P-Value | <0.0001 | 0.001 | <0.0001 | 0.002 | <0.0001 | 0.01 | |
β=beta coefficient from the model for the interaction term between MIND diet score and time
n=total number of participants with complete data for model
Basic model includes age at the first cognitive assessment, Mind diet score, sex, education, participation in cognitive activities, APOE-ε4 (any ε4 allele), smoking history (current, past, never), physical activity hours per week, total energy intake, time and interaction terms between time and each model covariate
Basic model plus history of stroke, myocardial infarction, diabetes, hypertension and interaction terms between each covariate and time
Composite score of the following 7 instruments: Immediate memory test and delayed memory test from Story A Logical Memory subset of the Wechsler Memory Scale-Revised; immediate word recall and delayed word recall of the CERAD Word List Recall; CERAD Word list Recognition; and immediate memory test and delayed memory test of the East Boston Story.
Composite score of the following 3 instruments: Verbal fluency from CERAD; 15 item version of the Boston Naming Test; and 15-item reading test
Composite score of the 15-item version of Judgment of Line Orientation and the 16-item version of Standard Progressive Matrice
Composite score of the following 4 measure: Oral version of the Symbol Digit Modalities Test; Number Comparison; and, 2 indices from a modified version of the Stroop Neuropsychological Screening test
Composite score of the following 3 instruments: Digit Span subtests-forward of the Wechsler Memory Scale-Revised; Digit Span subtests-backward of the Wechsler Memory Scale-Revised; and Digit Ordering