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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Clin Immunol. 2015 May 16;160(2):261–276. doi: 10.1016/j.clim.2015.05.005

Figure 8. Overview of B lymphocyte differentiation block in equine CVID patients based on transcriptome and epigenome data analyses.

Figure 8

Stages of B lymphocyte differentiation are shown at the top. Changes in methylation and gene expression shown for healthy bone marrow yielding successful B lymphopoiesis (top panel) and equine CVID patient bone marrow with diminished B lymphopoiesis (bottom panel). The block defined in equine CVID B lymphopoiesis is indicated by shading. * Data shown are statistically different from control samples.