Table 2. Final Cox proportional hazards model multivariable regression with effect estimates for overall survival (defined as time from diagnosis until death from all causes) and cause specific survival (defined as time from diagnosis until death due to cancer).

	Overall survival			Cause specific survival
	Hazard ratio	95% confidence interval of hazard ratio	P-value	Hazard ratio	95% confidence interval of hazard ratio	P-value
Gender
Female	1 (baseline)			1 (baseline)
Male	1.1	1.09-1.14	<0.0001	1.1	1.07-1.12	<0.0001
Age group
Age <65	1 (baseline)			1 (baseline)
Age 65+	1.4	1.40-1.45	<0.0001	1.3	1.31-1.36	<0.0001
Race
White	1 (baseline)			1 (baseline)
Black	1.2	1.12-1.19	<0.0001	1.1	1.10-1.17	<0.0001
Other	0.9	0.84-0.91	<0.001	0.9	0.84-0.91	<0.0001
Unknown	0.6	0.53-0.73	<0.0001	0.6	0.50-0.72	<0.0001
Relationship status
Single	1 (baseline)			1 (baseline)
Married/Partner	0.8	0.79-0.83	<0.0001	0.8	0.80-0.84	<0.0001
Separated/Divorced	1.0	0.94-1.01	0.17	1.0	0.94-1.01	0.1536
Widowed	1.1	1.06-1.13	<0.0001	1.1	1.06-1.14	<0.0001
Unknown	0.9	0.87-0.96	0.0001	0.9	0.87-0.97	0.001
Year of diagnosis
1988-1999	1 (baseline)			1 (baseline)
2000-2011	0.8	0.80-0.83	<0.0001	0.8	0.79-0.83	<0.0001
Site
Esophagus	1 (baseline)			1 (baseline)
Esophagus/GEJ	1.0	0.94-0.98	0.0003	1.0	0.94-0.98	<0.0001
Grade
I	1 (baseline)			1 (baseline)
II	1.2	1.14-1.25	<0.0001	1.2	1.18-1.30	<0.0001
III/IV	1.4	1.33-1.46	<0.0001	1.5	1.41-1.56	<0.0001
Unknown	1.2	1.17-1.28	<0.0001	1.3	1.21-1.34	<0.0001
Histology
Adenocarcinoma	1 (baseline)			1 (baseline)
Squamous cell	1.1	1.12-1.17	<0.0001	1.1	1.12-1.17	<0.0001
All others	1.1	1.11-1.17	<0.0001	1.2	1.12-1.19	<0.0001
Stage
Localized	1 (baseline)			1 (baseline)
Regional	1.4	1.38-1.45	<0.0001	1.6	1.54-1.63	<0.0001
Distant	3.0	2.91-3.06	<0.0001	3.5	3.44-3.63	<0.0001
Unknown	2.0	1.90-2.02	<0.0001	2.1	2.05-2.20	<0.0001