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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Bioorg Med Chem. 2015 Aug 25;23(19):6379–6388. doi: 10.1016/j.bmc.2015.08.025

Scheme 3.

Scheme 3

Reagents and conditions: a) Boc-L-isoleucine, HOBt, EDC, DIPEA, CH3CN; b) HCl, CH3OH; c) BH3 • S(CH3)2; d) Boc-7-hydroxy-D-Tic-OH, EDC • HCl, DIPEA, HOBt, THF; e) HCl, CH3CN, dioxane.