Fig. 1.

HGA concentrations measured in urine. (a) Comparison of mean HGA levels of six patients evaluated at both 2 and 4 mg/day NTBC. The average fold change in HGA concentration was 2.7-fold (* indicates p-value of 0.01 from paired t-test analysis). (b) Urine HGA comparison between 4 and 6 mg/day NTBC dosage (fails null hypothesis testing, p-value >0.05). (c) Urine HGA concentrations plotted versus NTBC plasma concentration and fit to a single exponential decay curve. Plasma was acquired from the same day as the 12-h urine collection. The region of the graph corresponding to values of samples acquired after NTBC treatment is shown zoomed in. (d) Mean urine HGA concentrations plotted versus NTBC dosage. Standard deviations are depicted by error bars