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. 2015 Aug 30;42(5):447–462. doi: 10.1007/s10928-015-9437-x

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — The relationship between drug concentration and the intensity of the biological response depends on drug- and biological system specific factors. Drug specific properties are the target binding affinity and the intrinsic efficacy, which govern the target activation. A biological system-specific transducer function describes the relation between the target activation and the effect. Reproduced from: van der Graaf and Danhof [67]