Table 2.

Influence of abnormal physiological conditions on the pharmacodynamics of CNS depressants and CNS stimulants

	CNS depressant drugs	CNS stimulating drugs
Pregnancy	Effect of pregnancy on phenobarbital concentrations at onset of loss of righting reflex in rats [93] Effect of pregnancy on ethanol concentrations at onset of loss of righting reflex in rats [10]a	Effect of pregnancy on the relationship between phenytoin concentration and antiseizure activity in rats [94]
Body temperature, fever	Effect of experimental fever on phenobarbital concentrations at onset of loss of righting reflex in rats [95]	Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats [96] Effect of body temperature on the convulsant activity of pentylenetetrazol in rats [97]
Acute hypovolemia	Effect of acute hypovolemia on the pharmacodynamics of phenobarbital in rats [98] Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam [99] Effect of hypovolemia on the pharmacodynamics of zoxazolamine in rats [100]	Effect of acute hypovolemia on theophylline-induced neurotoxicity in rats [101]
Food or fluid imbalances	Effects of acute starvation on the pharmacodynamics of phenobarbital, ethanol and pentylenetetrazol in rats and effects of refeeding and diet composition [102]b Effects of acute fluid overload and water deprivation on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline in rats [103]b	Effects of acute starvation on the pharmacodynamics of phenobarbital, ethanol and pentylenetetrazol in rats and effects of refeeding and diet composition [102]b Effects of acute fluid overload and water deprivation on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline in rats [103]b
Adrenalectomy, corticosterone treatment	Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats [104]b	Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats [104]b
Nicotine	Effect of nicotine on the pharmacodynamics and pharmacokinetics of phenobarbital and ethanol in rats [105]
Drug-drug interactions	Effect of cyclosporine on the pharmacodynamics and pharmacokinetics of a barbiturate (heptabarbital) in rats [106] Potentiating effect of l-tryptophan on the hypnotic action of phenobarbital and ethanol in rats [107] Effects of contraceptive steroids on the pharmacodynamics of ethanol in rats [108]

Most titles in this table are shortened titles. Full titles of the published papers include Kinetics of Drug Action in Disease States, followed by a number (I-XLV), and the short title represented in this table

^aTitles are the full title of the published paper

^bIf both CNS depressants and CNS stimulants are reported in one published paper, the paper is mentioned twice in the table