Table 4.

Influence of systemic components of renal dysfunction on the pharmacodynamics of CNS depressants and CNS stimulants

CNS depressants

Effect of dialyzable component(s) of uremic blood on phenobarbital concentrations in rat at onset of loss of righting reflex [42] Acute effect of urea infusion on phenobarbital concentrations in rats at onset of loss of righting reflex [24] Effect of elevated plasma creatinine concentrations on the hypnotic action of phenobarbital in normal rats [116] Effect of experimental nephrotic syndrome on the pharmacodynamics of heptabarbital: Implications of severe hypoalbuminemia [43]

CNS stimulants

Effect of the dialyzable component(s) of uremic blood on theophylline neurotoxicity in rats [117]

Titles in this table are shortened titles. Full titles of the published papers include Kinetics of Drug Action in Disease States, followed by a number (I-XLV), and the short title represented in this table