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. 2015 Aug 30;42(5):447–462. doi: 10.1007/s10928-015-9437-x

Table 5.

Overview of studies in which a continuous measurement of the pharmacological effect was used together repeated measurement of pharmacokinetics

Drug Endpoint
Benzodiazepines + related GABA receptor agonists EEG parameters [29, 60, 66]
Cyclopentyl-adenosine A1 receptor agonists Hemodynamic parameters [31]
Biochemical parameters: lipolysis [118]
Opioids EEG effect parameters [119, 120]
Anti-nociceptive effect; Respiratory depression [71, 121]
5-HT1A receptor agonists Body temperature [64, 83]
Dopamine D2 receptor agonists Receptor occupancy [122, 123]
Prolactin responses [61]