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. 2015 Sep 1;8(9):1027–1035. doi: 10.1242/dmm.019547

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Craniofacial phenotype of WHSC1 mutant mice. E16.5 wild-type and mutant heads (A-F) and transverse sections (G,H) stained for Picro-Sirius red trichrome. WHSC1^−/− mice have the characteristic broad, flat nasal bridge, prominent glabella, short philtrum and micrognathia observed in individuals with WHS, as well as microtia and hypertelorism. The middle and inner ear morphology are normal. Scale bars: 500 μm (A-F); 200 μm (G,H). Arrow, pit in the outer ear; arrowhead, eustachian tube; black asterisk, ear canal; yellow asterisk, middle ear bones; iec, inner ear capsule; v, vestibule; c, cochlea.