Fig. 8.

Schematic of the VEGF-A/NRP1 signaling pathway to promote cancer cell proliferation. Schematic of a new pathway of NRP1 signals leading to the proliferation of cancer cells. Cancer cell-secreted VEGF-A binds to NRP1 in an autocrine manner and stimulates complex formation by GIPC1, a scaffold protein, and Syx, RhoGEF, via the NRP1 cytoplasmic region. The GIPC1/Syx complex increases the activation of RhoA in order to induce the degradation of p27 and consequently promotes cancer cell proliferation.