Table 3.
Univariable Cox Regression Analyses of CVD Deaths in Men Diagnosed With Testicular Nonseminoma According to Baseline Characteristics
| Variable | No. of Patients | All CVD Deaths (n = 104) |
|||
|---|---|---|---|---|---|
| No. of CVD Deaths | HR | 95% CI | P | ||
| Initial treatment by time since TC diagnosis* | |||||
| < 1 year | |||||
| Surgery (no RT) | 8,097 | 2 | — | — | Ref |
| Chemotherapy (no RT) | 6,909 | 11 | 6.52† | 1.75 to 42.12 | < .01 |
| 1-4 years | |||||
| Surgery (no RT) | 7,388 | 9 | — | — | Ref |
| Chemotherapy (no RT) | 6,014 | 12 | 1.73 | 0.73 to 4.25 | .21 |
| ≥ 5 years | |||||
| Surgery (no RT) | 5,369 | 39 | — | — | Ref |
| Chemotherapy (no RT) | 3,973 | 31 | 1.15 | 0.72 to 1.85 | .55 |
| Age at TC diagnosis, years | |||||
| < 30 | 8,620 | 23 | — | — | Ref |
| 30-39 | 4,254 | 34 | 3.10† | 1.84 to 5.34 | < .01 |
| 40-49 | 1,602 | 23 | 7.68† | 4.27 to 13.80 | < .01 |
| ≥ 50 | 530 | 24 | 28.96† | 16.22 to 51.82 | < .01 |
| Calendar year of diagnosis | |||||
| 1980-1989 | 2,316 | 51 | — | — | Ref |
| 1990-1999 | 3,350 | 29 | 0.87 | 0.52 to 1.46 | .60 |
| 2000-2010 | 9,340 | 24 | 0.87 | 0.46 to 1.65 | .66 |
| Extent of disease | |||||
| Localized | 8,747 | 46 | — | — | Ref |
| Regional | 3,521 | 34 | 1.58† | 1.01 to 2.46 | .04 |
| Distant | 2,601 | 23 | 2.20† | 1.31 to 3.59 | < .01 |
| Unknown | 137 | 1 | 0.87 | 0.05 to 3.97 | .89 |
| Race | |||||
| White | 14,087 | 98 | — | — | Ref |
| Nonwhite | 919 | 6 | 1.16 | 0.45 to 2.43 | .73 |
| County education level‡ | |||||
| Education 1 (low) | 3,310 | 30 | — | — | Ref |
| Education 2 (medium) | 6,575 | 53 | 1.00 | 0.65 to 1.59 | .99 |
| Education 3 (high) | 5,120 | 21 | 0.83 | 0.46 to 1.45 | .51 |
| Unknown | 1 | 0 | 0 | NA to 68.05 | .99 |
| Marital status | |||||
| Never married | 8,350 | 37 | — | — | Ref |
| Married | 5,481 | 54 | 1.92† | 1.27 to 2.93 | < .01 |
| Separated/divorced/widowed | 670 | 9 | 3.35† | 1.52 to 6.64 | < .01 |
| Unmarried/domestic partner/unknown | 505 | 4 | 2.37 | 0.71 to 5.91 | .10 |
Abbreviations: CVD, cardiovascular disease; HR, hazard ratio; NA, not applicable; Ref, reference; RT, radiotherapy; TC, testicular cancer.
The number of person-years (PY) is as follows: < 1 year (surgery: 81,227 PY; chemotherapy: 60,065 PY); 1 to 4 years (surgery: 80,946 PY; chemotherapy: 59,655 PY); and ≥ 5 years (surgery: 75,054 PY; chemotherapy: 54,070 PY).
HR with P < .05.
County education level was categorized based on tertiles of distribution, as follows: education 1 represents the lowest level (composed of counties with ≥ 25% of men without a high school education); education 2 represents the medium level (counties with 15% to < 25% of men without a high school education); and education 3 represents the highest level (counties with < 15% of men without a high school education).